In the match, held at the Foolad Arena in Ahvaz, Hojat Ahmadi and Amir Hossein Jalalivand scored two goals for the host to seal a home win.
Esteghlal Khuzestan moved up to 10th in the 16-team table, while Zob Ahan remained 13th, two points above relegation zone.
On Friday, rock-bottom Mes will host Persepolis in Rafsanjan, Aluminum meet Malavan in Arak, Shams Azar face Tractor in Qazvin and Fajr Sepasi play Foolad in Shiraz.
Sepahan leads the table with 27 points, two points above Persepolis.