Witnesses said targets included the police academy and the headquarters of the security services, both in the heart of the capital which has been controlled by the Houthis since September last year.
Overnight strikes also hit the Sana'a residences of Houthis, witnesses said, according to AFP.
The strikes followed reports that Persian Gulf Arab members of the Saudi-led coalition had sent thousands of heavily armed reinforcements to Yemen after a Houthi missile attack killed 60 coalition soldiers Friday.
The additional troops, most of them from Qatar and Saudi Arabia, were deployed to the battleground eastern oil province of Marib where the attack took place, the reports said.
The coalition launched its air war against the Houthis when resigned President Abed Rabbou Mansour Hadi fled to neighboring Saudi Arabia in March after they entered his last refuge, Yemen's second city Aden.