Heading a delegation, General Dehqan will visit the African country at the official invitation of his South African counterpart Nosiviwe Noluthando Mapisa-Nqakula.
During his two-day trip, the Iranian minister will hold meetings with senior officials of South Africa on bilateral, international and regional issues.
An agreement on defense and military cooperation between the two countries is expected to be signed during the visit.
Iranian President Hassan Rouhani, who took office in August 2013, has repeatedly stressed his administration’s interest in boosting relations with African states.
Back in April, South African President Jacob Zuma paid an official visit to Iran, during which the two sides signed a number of agreements to develop bilateral ties.