The Uzbek star was substituted off in the match against Aluminum due to an injury.
Persepolis had previously announced that Urunov has no serious problem and would be ready for the match against Esteghlal but the player is not fit for the match, slated for Wednesday in Arak.
The Tehran derby will be very crucial for two teams, especially for Esteghlal, who have earned just five points out of five matches in the 2024-25 Iran Professional League (IPL).
Esteghlal captain Rouzbeh Cheshmi will be absent against Persepolis after he was shown a red card in the match against Nassaji in IPL Matchday 5.