Esteghlal defeated first tier Paykan 1-0 in Tehran’s Azadi Stadium. Ramin Rezaeian found the back of the net from the penalty spot in the 74th minute.
Defending champion Sepahan lost to Malavan 4-2 on penalties after the match ended in a goalless draw.
Later in the day, Sanat Naft defeated Shahrdari Noshahr 1-0 in Abadan and advanced to the semifinals.
Gol Gohar had previously advanced to the semifinals by defeating Nassaji 3-1 in Ghaemshahr on Friday.
Esteghlal and Persepolis are the most successful clubs with seven titles each in the Hazfi Cup.