In a post on his X account, Pezeshkian emphasized that the notion of erasing Iran from existence is an expression of failure to engage with a historically significant nation.
The president noted that such hostile threats only serve to unite the public even further.
He also asserted that the Strait of Hormuz remains accessible to all nations, with the exception of those that act aggressively toward Iran.
Pezeshkian then cautioned that Iran will react decisively to reckless statements and threats, promising a strong response on the battlefield to any provocations.
The US and the Israeli regime launched a large-scale unprovoked military campaign against Iran following the assassination of Leader of the Islamic Revolution Ayatollah Seyed Ali Khamenei, along with several senior military commanders and civilians on February 28.
The attacks have involved extensive aerial strikes on both military and civilian locations across Iran, causing significant casualties and widespread damage to infrastructure.
In response, the Iranian Armed Forces have carried out retaliatory operations, targeting American and Israeli positions in the occupied territories and at regional bases with waves of missiles and drones.