One victim remained hospitalized in critical condition, the police said, Reuters reported.
Troopers were dispatched around 11.40am local time (1540 GMT) to a home in Missaukee County, Michigan, after a report of a shooting. Officers found three people dead and a fourth person wounded, the state police said.
The suspect, identified by police as 39-year-old Chad Hickman, fled the scene before troopers arrived, prompting a manhunt.
During the search for the suspect, investigators discovered another deceased victim at a second residence.
Troopers later located Hickman's vehicle near a wooded area close to Whitlock Lake, where they found Hickman and another person dead, police said.
"This situation is heartbreaking for the community and challenging for the investigators involved," said Lieutenant Ashley Miller, cited in the police statement.
Police did not release the names, ages or genders of the victims, saying next-of-kin notifications were underway.