The execution at Riverbend Maximum Security Institution in Nashville would also make Pike the first person in modern US death penalty history to be executed for a crime committed at age 18, according to the Death Penalty Information Center.
Pike, her boyfriend Tadaryl Shipp and another teenage girl, Shadolla Peterson, lured Slemmer into woods near Knoxville in January 1995 after meeting her through the Knoxville Job Corps.
According to court records and trial testimony, Slemmer was stripped, beaten and tortured before Pike attacked her with asphalt and a knife, while Shipp carved a pentagram into her chest.
Pike was the only one of the three to receive a death sentence.
Shipp was 17 at the time and received life in prison, while Peterson testified against the pair and received probation.
Pike’s execution date has prompted appeals from more than 100 organizations and experts, who have urged Tennessee Gov. Bill Lee to commute her sentence to life without parole.
On Monday, Lee rejected a 226-page clemency petition submitted by Pike’s attorneys.
“After deliberate consideration of Christa Gail Pike’s request for clemency, and after a thorough review of the case, I am upholding the sentence of the State of Tennessee and do not plan to intervene,” Lee said.
The petition focused heavily on Pike’s childhood, detailing repeated sexual abuse, neglect and mental health problems.
According to her attorneys, Pike was sexually assaulted between the ages of 2 and 5 by a family member’s boyfriend, raped by a neighbor at 11 and sexually assaulted again by a stranger at 17.
Her attorneys also cited evidence that her mother’s heavy drinking during pregnancy contributed to neurological problems later associated with bipolar disorder.
They argue that the trauma and mental illness were inadequately presented by Pike’s original defense team and should have been considered when she was sentenced.
Earlier this month, UN human rights experts also called for the execution to be halted, citing Pike’s history of severe childhood abuse, neurological impairments and mental health conditions.
Meanwhile, Pike has nearly exhausted her legal appeals.
The Tennessee Supreme Court rejected her request for a stay last week, while a separate appeal remains pending before the US Supreme Court.
A special master appointed by the Tennessee Supreme Court also examined whether the state’s execution procedures could expose Pike to unconstitutional suffering.
Her attorneys challenged Tennessee’s lethal-injection protocol, citing a botched execution attempt earlier this year and arguing that Pike’s blood disorder and small veins could increase the risk of complications, severe pain and bleeding.
Pike requested execution by hanging instead, but Senior Judge W. Mark Ward ruled that Tennessee’s protocol would not violate her constitutional rights.
If the execution proceeds, Pike would become the 19th woman executed in the United States since the death penalty was reinstated in 1976.
For Slemmer’s family, the case remains centered on the loss of a daughter.
Slemmer’s mother, May Martinez, has said she plans to travel from Florida to Tennessee to witness the execution, carrying a photograph of her daughter.